Fig. 3
Stemness-related signaling pathways stimulated by the immune system. Neu, neutrophil; MSC, mesenchymal stem cell; CSC, cancer stem cell; EMT, epithelial mesenchymal transition; Treg, T regulatory lymphocyte; Shh, Sonic hedgehog. The Notch pathway regulates the balance between Th17 and Treg. The immune microenvironment regulates tumoral process such as EMT and expression of stemness markers, as well as immune evasion