Fig. 1From: Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapyHDR gene-editing. Cas9-RNP along with a donor template (AAV6 or ssODN or IDLV) is delivered into HSPCs. Cas9 RNP introduces DNA double-stranded breaks at the target locus and endogenous HDR pathway repairs the DNA damage. During this process, the donor template having homologous sequence to the cut site is inserted into the target locusBack to article page