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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor

Fig. 3

Skeletal muscle repair and the number of SCs were reduced in aged mice. AC The proportions of fibrotic and necrotic muscle cells were not significantly different between the aged and young mice on the 3rd day after TA injury (n = 8) (t = 0.931 and 0.116, P = 0.368 and 0.910). D, E On the 42nd day after injury, the proportion of fibrosis in the aged mice was higher than that in the young mice, and the muscle cell area in the aged mice was smaller than that in the young mice (n = 8) (t = 3.911 and 2.897, P = 0.002 and 0.012). FJ The numbers of PAX7+ SCs (white and red arrow) and self-renewing PAX7+Myf5 SCs (red arrow) were decreased substantially in aged mice compared with young mice on days 10 (n = 8) (t = 8.341 and 6.24, both P < 0.001) and 42 (n = 8) (t = 9.815 and 4.825, both P < 0.001) after injury. K, L The number of PAX7+ (SCs) in aged mice and CS-treated mice was reduced, and CLB partially reversed this decrease (F = 14.912, P < 0.001). Independent samples t tests and one-way ANOVA with Tukey’s test, ns, not significant, *P < 0.05; **P < 0.001

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