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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis

Fig. 5

Effect of circulating TGF-β1 on Treg induction and BLM-induced pulmonary fibrosis. A The heatmap shows the gene expression related to the regulation of TGF-β production between S-MSCs (S1-3) and SF-MSCs (SF1-3). Each row represents a sample, and each line represents an expressed gene. Red color indicates upregulation and blue color indicates downregulation. B Experimental scheme of systemic TGF-β1 supplementation. ip, intraperitoneal injection. C The hydroxyproline content in the murine left lung (n = 5–7 per group). D The percentages of blood or lung Tregs in BLM-treated mice with or without TGF-β1 injection (n = 4–5 per group). Data are presented as means ± SD. *P < 0.05. ****P < 0.001

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