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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathway

Fig. 1

Endogenous SerpinB2 expression and the influence of exogenous recombinant SerpinB2 on the proliferation and osteogenesis differentiation of hBMSCs. a–c SerpinB2 expression level decreased during osteogenic differentiation of hBMSCs. d SerpinB2 didn’t influence hBMSC proliferation. e–g hBMSCs were incubated with different concentrations (0–100 ng/ml) of recombinant SerpinB2 for 3 days. The mRNA expression of COL1A1 and SP7 decreased dramatically by SerpinB2. h–k The expression of COL1A1, RUNX2 and SP7 protein levels also decreased significantly with SerpinB2 (0–100 ng/ml). All data are expressed as mean ± SD. Assays were performed in triplicate. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 compared with the control group

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Stem Cell Research & Therapy

ISSN: 1757-6512