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Table 1 Etiology of refractory peptic ulcers

From: Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer

The most common causes of refractory peptic ulcers

Less common causes of refractory peptic ulcers

Rare causes of refractory peptic ulcers

Persistent H. pylori infection

Continued NSAID Use

Medications

Aspirin

Radiation therapy

Crack cocaine use

Mesenteric ischemia

Malignancy (gastric/lung cancer, lymphomas)

Gastric acid hypersecretion (retained antrum syndrome and Zollinger–Ellison syndrome)

Other viral and bacterial infections (TB, Syphilis, CMV, HPV)

Sarcoidosis

Behçet disease

Polyarteritis nodosa

Crohn disease

Vasculitides

Smoking

Stress (acute illness, burns, head injury)

Chemotherapy