Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation

Fig. 3

LRRK2 phosphorylation and α-synuclein accumulation in DA neurons derived from iPSCs. a, b Western blotting demonstrated reduced phosphorylation of Ser1292 in LRRK2 and a, c Ser129 in α-synuclein. a, d Increased levels of α-synuclein were also observed in iPSCs carrying the LRRK2 p.G2019S mutation (G2019S) compared to wild-type iPSCs (WT). Isogenic clones (ABE01 and HDR26) with corrected mutations rescued these phenotypes for Parkinson’s disease. Western blotting was performed in triplicate. *P < 0.05 compared to WT, ABE01, and HDR26

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512