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Table 1 Summary of fertility recovery study

From: Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency

 

H-CTR

H-CH

H-IV

Number of animals

7

8

8

Total number of pups

88.9 ± 20.6

24.5 ± 17.3 d 1

36.3 ± 19.2 d 1

Number of pups/litter (months 1–4)

14.5 ± 1.3

10.3 ± 2.1 a 1

9.5 ± 2.2 b 1

Number of litters

6.6 ± 1.1

2.3 ± 1.3 d 1

3.8 ± 1.3 c 1, * 2

Months of fertility from w-1

7.9 ± 1.2

2.4 ± 1.4 d 1

4.1 ± 1.7 c 1, * 2

Pregnancy rate (up to 1 litter)

100% (7/7)

100% (8/8)

100% (8/8)

Pregnancy rate (up to 2 litters)

100% (7/7)

62.5% (5/8) a 1

100% (8/8) * 1

Pregnancy rate (up to 3 litters)

100% (7/7)

37.5% (3/8) c 1

87.5% (7/8) ** 1

Pregnancy rate (up to 4 litters)

100% (7/7)

25% (2/8) d 1

50% (4/8) b 1

Pregnancy rate (up to 5 litters)

100% (7/7)

–

25% (2/8) d 1

Pregnancy rate (up to 6 litters)

85.7% (6/7)

–

12.5% (1/8) d 1

Pregnancy rate (up to 7 litters)

42.9% (3/7)

–

–

Pregnancy rate (up to 8 litters)

28.6% (2/7)

–

–

Pregnancy rate (up to 9 litters)

–

–

–

  1. 1Significance is calculated with One-way ANOVA vs CTR (letters) and vs CH (asterisks) as described in "Methods" section
  2. 2Significance is calculated with t-test vs CH (asterisks) as described in "Methods" section