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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

Fig. 2

FNDC5-MSCs‐Exo administration reduced post‐infarction inflammation and increased M2 macrophage polarization in vivo. a Representative images of inflammatory cells infiltration within the infarct border zone at 3 and 7 days were illustrated by H&E staining. Serum inflammatory cytokines (TNF‐α and IL-6) at 3 days (b, c) and 7 days (d, e) were assayed by ELISA. Western blot analysis of CD206 protein at 3 days (f) and 7 days (g). Representative semi-quantification analysis of CD206 at 3 days (h) and 7 days (i). Data are expressed as the means ± SEM; n = 5; *P < 0.05

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