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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

Fig. 5

rhMG53 and hUC-MSCs reduce oxidative stress and cell death and increase neurogenesis after TBI. Quantification of the concentration of GSH (a) and SOD (b) and activity of MDA (c) at day 3 post-TBI. d PI staining in the cerebral cortex of TBI mice as a marker for cell death at 3 days post-TBI. Scale bar = 100 μm. e Quantification of the number of PI-positive cells in the four groups. Western blotting (f) and densitometric analysis (g) of Bcl-2 and Bax in the hippocampus of different TBI mice. h Immunofluorescence staining of GFAP + , DCX + , and NeuN + cells in the brain of the mice. Scale bar = 100 μm. Quantification of the number of GFAP + (i), DCX + (j), and NeuN + (k) cells in the four groups. l qRT-PCR for BDNF and NGF. Data were presented as mean ± SEM. n = 6 per group. *p < 0.05, compared with TBI group; #p < 0.05, compared with MG53 + MSC group

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