Fig. 3

Unique clonal sharing pattern between different tissues. Polar area plots of clonal expansion and sharing in peripheral blood, spleen, and bone marrow (BM). There are three axes, one for each tissue. Stacked bar plot on each axis shows size distribution of clones in the tissue. Each colored stack represents a VIS clone and its thickness shows abundance of the clone. Clones shared between tissues are connected using ribbons with colors matching the clone’s stack color in the bar plot. Black line encompasses total size distribution of persistent clones that continuously contributed from week 13 till 19. Clones did not continuously contribute for 6 weeks and were detected at week 19 in blood, spleen, and BM are outside black line. Pearson’s r values are shown in black. Bar plots on the right show the percentage of human lymphocytes (huCD45 + cells within the total lymphocytes), human T cell (CD3 + within huCD45 population), and human B cell (CD19 + within huCD45 population) in blood, BM, and spleen of each animal