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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Endometrial regenerative cells with galectin-9 high-expression attenuate experimental autoimmune hepatitis

Fig. 8

Application of Gal-9 high-expressing ERCs in ConA-induced experimental autoimmune hepatitis in mice. ERCs are isolated from menstrual blood and transfected with GFP-Gal-9-LVs in vitro. After expansion, in vitro co-culture and in vivo administration, the results show that Gal-9 high-expressing ERCs effectively restore the liver function, ameliorate liver pathological damage, inhibit CD4+ and CD8+ T cell proliferation and suppress Th1 and Th17 cell response in the hepatitis mice. Additionally, Gal-9 high-expressing ERCs also markedly enhance the level of IL-10, but reduce the levels of IFN-γ, TNF-α, and IL-4 in mouse sera and liver. In addition, it also indicates that Gal-9 high-expressing ERCs inhibit CD4+ T cell activation in vitro, and proves that this inhibition is associated with the inactivation of Lck/ZAP-70/LAT pathway. These results would provide a novel idea for the clinical treatment of AIH. (Created by using www.biorender.com software)

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