Fig. 1

EPC-secretome from stroke patients promotes in vitro angiogenesis. EPC-secretome obtained from stroke patients (scSP-CM) and healthy donors (scHD-CM) under low-scale production conditions have similar effects on CD34⁺-ECs proliferation (a), migration (b), and tubulogenesis (c). Further, EPC-secretome obtained from stroke patients produced at high-scale conditions (scCM) increased CD34⁺-ECs proliferation (d), migration (e), and tubulogenesis (f). Besides, two scCM batches were compared and showed similar effects (scCM-1, batch 1; scCM-2, batch 2). The effects of scCM were similar to those observed with VEGF-A (50 ng/mL). Data represent median (interquartile range) (n = 3–8), *P < 0.05 vs scEBM. Scale bar: 200 μm