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Table 3 Pathways overrepresented in CMECs treated with scCM

From: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Reactome Pathways Homo sapiens (n) scCM (n) scCM (expected) Fold enrichment P-value
Interferon alpha/beta signalling (R-HSA-909733) 67 9 .07  > 100 1.25E−13
Interferon Signalling (R-HSA-913531)‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬ 196 9 .22 41.12 1.19E−09
Cytokine Signalling in Immune system (R-HSA-1280215) 823 12 .92 13.06 3.34E−08
Interleukin-10 signalling (R-HSA-6783783) 45 3 .05 59.70 4.20E−02
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410) 79 4 .09 45.34 4.22E−03
  1. Upregulated genes (23 genes) in scCM-treated CMECs were analysed by the Panther software based on the human database. Pathways (Reactome database) which were overrepresented (fold enrichment) were mainly related to IFN and inflammatory pathways. N: number of genes found in the human genome (Homo sapiens) or scCM; Expected: number of genes expected for a certain pathway based on the Reactome database; Fold enrichment: scCM (n)/scCM (expected)