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Table 3 Pathways overrepresented in CMECs treated with scCM

From: RETRACTED ARTICLE: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Reactome Pathways

Homo sapiens (n)

scCM (n)

scCM (expected)

Fold enrichment

P-value

Interferon alpha/beta signalling (R-HSA-909733)

67

9

.07

 > 100

1.25E−13

Interferon Signalling (R-HSA-913531)‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬

196

9

.22

41.12

1.19E−09

Cytokine Signalling in Immune system (R-HSA-1280215)

823

12

.92

13.06

3.34E−08

Interleukin-10 signalling (R-HSA-6783783)

45

3

.05

59.70

4.20E−02

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

79

4

.09

45.34

4.22E−03

  1. Upregulated genes (23 genes) in scCM-treated CMECs were analysed by the Panther software based on the human database. Pathways (Reactome database) which were overrepresented (fold enrichment) were mainly related to IFN and inflammatory pathways. N: number of genes found in the human genome (Homo sapiens) or scCM; Expected: number of genes expected for a certain pathway based on the Reactome database; Fold enrichment: scCM (n)/scCM (expected)