From: The safety of MSC therapy over the past 15 years: a meta-analysis
Principle | Inclusion criteria | Exclusion criteria |
---|---|---|
Population | Any populations including the healthy people and the diseased people | NA |
Intervention | Using MSC as treatment, regardless of the administration methods (e.g. local implantation and injection) and sources of MSC (e.g. from the adipose, bone marrow and gum) | Using NSC, ESC, olfactory neuron, Schwann cell, h-IPS and stem cell from body fluids (e.g. saliva, urine, serum and tears), etc. but MSC as interventions |
Comparison | Placebo treatment, nontreatment or basic treatment both utilized in the control and the intervention groups | Merely using traditional treatment (surgery and drug) in the control group but not in the intervention group |
Outcome | (1) Any side events associated with MSC treatment; (2) one side event reported by more than one study; (3) regardless of the efficacy of MSC therapy for any diseases | No side events reported |
Study | (1) RCT; (2) prospective controlled study | (1) Case report (series); (2) single-arm study; (3) retrospective controlled study; (4) cross-controlled study; (5) study protocol |