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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat

Fig. 2

Ultrasound studies of common carotid artery (CCA) and the ratio of recanalization to ≤ 50% stenosis in the 5 treatment groups at 4 time points after 6 mW/cm2 LED irradiation for 4 h. CCD lumen is completely occluded at A, B and D groups from 2 h, 24 h, 4 days to 7 days. However, CCA lumen is occluded at 2 h but progressively recanalized from 24 h, 4 days to 7 days at C and E groups. A  LED irradiation alone (LED group), B LED irradiation plus intravenous bolus injection of 0.45 mg/kg rt-PA alone (0.45 mg/kg rt-PA group), C  LED irradiation plus intravenous bolus injection of 0.9 mg/kg rt-PA alone (0.9 mg/kg rt-PA group), D LED irradiation plus intravenous bolus injection of 1 × 106 iPSCs alone (iPSCs group), E LED irradiation plus intravenous bolus injection of 0.45 mg/kg rt-PA and 1 h later, bolus injection of 1 × 106 iPSCs (0.45 mg/kg rt-PA plus iPSCs group). LED = light-emitting diode; n = 8 in each group. Arrow indicates carotid bifurcation. Arrowhead and dot-line indicate the stenosis segment. h = hour; d = day. Scale bar in A (2 h) = 1 mm

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