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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose

Fig. 5

The mechanism of IGF-1R inhibiting osteogenic differentiation of PDLSCs stimulated by high glucose. a Under normal condition, the regenerative function of the alveolar bone around the teeth is stable and PDLSCs can differentiate into osteoblasts and other multifaceted differentiation. Whereas in diabetic patients, the alveolar bone is gradually resorbed and the teeth are loosened, IGF-1R overexpressed. b In this study, osteogenic medium with high glucose concentration were used to culture PDLSCs to mimic the periodontal tissue microenvironment of diabetic patients. Under the stimulation of high glucose, the level of IGF-1R located on the cell membrane significantly increased, along with the enhancement of SUMO modifications. Subsequently, sumolylation of IGF-1R inhibited downstream osteogenic-related proteins by entering the nucleus and combining with SNAI2, resulting in reduced osteogenic differentiation of PDLSCs under high glucose environment. IGF-1R the insulin-like growth factor 1 receptor, SUMO1 Small Ubiquitin Like Modifier 1, SNAI2 Snail Family Transcriptional Repressor 2, RUNX2 RUNX Family Transcription Factor 2, PDLSCs Periodontal ligament stem cells

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