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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Valproic acid promotes the in vitro differentiation of human pluripotent stem cells into spermatogonial stem cell-like cells

Fig. 4

Transcriptome analysis of hiPSCs and cells at 12 days of differentiation. A The volcano plot of DEGs between hiPSCs (Day 0) and cells at 12 days of differentiation (Day 12), red dots represented significantly upregulated genes, green dots represented significantly downregulated genes and black dots represented not significantly changed genes. B GO terms (biological process) of upregulated and downregulated genes, respectively. C Heatmap of significantly changed genes between Day 0 and Day 12 cells. D The expression of Wnt signaling pathway genes and methylation-related genes at different days of differentiation detected by RT-qPCR, n = 3

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Stem Cell Research & Therapy

ISSN: 1757-6512