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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy

Fig. 6

A summary diagram that leptin promotes megalin expression mediated by inhibition of CMA and synergistically with 25(OH)D3 to promote the osteoblast differentiation of rBMMSCs. As indicated by these studies, leptin inhibited the activity of CMA by activating PI3K/AKT signaling pathway to promote the expression of megalin, and then the quantity of 25(OH)D3 entering rBMMSCs was increased through increased megalin receptors. 25(OH)D3 was converted to 1α,25(OH)2D3 by 1α-hydroxylation of mitochondrial CYP27B1, and the synthesis of 1α,25(OH)2D3 was up-regulation and stimulated osteoblast differentiation of rBMMSCs

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