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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Immune response to allogeneic equine mesenchymal stromal cells

Fig. 6

B cell, T cell and CD8moderate/ CD25+ lymphocyte counts in co-culture at Day 3 (a, c, e) and Day 5 (b, d, f). B cell counts increased in PBMC only wells over time. Lower ratios of MSCs to PBMCs caused greater B cell counts. Significant differences between the co-culture groups are shown with brackets. Tregs were increased in 1:1 MSC/PBMC co-cultures as compared to cultures with a greater ratio of PBMCs. Blood donor co-cultures had consistently higher Tregs than other co-cultures. Total CD8moderate/CD25+ lymphocyte count illustrates elevated counts in MHC II-high co-cultures at Day 3 (e) and 5 (f). A representative sample of CD8moderate/ CD25+ lymphocytes is shown as the gated sample (black circle) (g). Significant differences between the co-culture groups are shown with brackets

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