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Table 1 MHC I expression on MSCs prior to and during co-culture with PBMCs

From: Immune response to allogeneic equine mesenchymal stromal cells

  Day 0 Day 3 Day 5
Control 1:1 1:10 1:100 Control 1:1 1:10 1:100 Control
Autologous 100 (2.3)ab 98.1 (0.2)a 98.2 (0.7)a 99.4 (0.2)a 98.3 (1.0)a,b 100 (0.5)a 93.8 (6.3)a 100 (0)a 99.9 (0.2)a,b
Blood donor 98.3 (6.1)a 98.5 (0.5)a 99.2 (0.5)a,b 99.5 (0.5)a 96.1 (18.2)a,b 99.6 (0.3)a 100 (0.4)a 98.8 (1.4)a 97.9 (12.0)a,b
MHC II-high 100 (0.6)b 99.8 (0.2)a 98.9 (2.4)a 99.8 (0.2)a 99.4 (1.1)a 99.5 (0.4)a 99.2 (1.4)a 99.7 (0.8)a 100 (0.2)a
MHC II-low 99.5 (0.6)ab 99.7 (0.5)a 99.7 (0.5)b 99.8 (0.1)a 93.2 (3.0)b 99.9 (0.2)a 100 (0.5)a 99.7 (2.7)a 97.2 (1.6)b
  1. Median percent of MSCs expressing MHC I and the interquartile range (IQR) are shown for control cultures (no PBMCs) and for co-cultures with the ratio of MSC/PBMC. Values within each column which have different letters are significantly different (p < 0.05). Autologous, autologous MSC co-culture (n = 1); blood donor, universal blood donor MSC co-culture (n = 3); MHC II high, MHC II-high MSC co-culture (n = 3), MHC II low, MHC II-low MSC co-culture (n = 3)