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Table 3 Lymphocyte activation during co-culture with MSCs

From: Immune response to allogeneic equine mesenchymal stromal cells

  Day 3 Day 5
1:1 1:10 1:100 Control 1:1 1:10 1:100 Control
Autologous 4795
(986)a
2092
(109)a
4973
(86)a,b
16,435
(7688)a,#
8349
(272)a,#
8473 (8292)a,b
Blood donor 6882
(3570)a,#
2449
(494)a
4319
(1162)a
11,156
(12,090)a,b
5818
(1572)a
15,215 (7230)a,#
MHC II-high 9986
(6166)a,#
4996
(2114)b
7805
(5145)b,#
11,135
(3348)a,b
7416
(1110)a,#
7241 (2015)b
MHC II-low 5380
(4573)a
2202
(317)a
3800
(2815)a
7686
(3961)b
5787
(1819)a
9493 (5314)a,b
PBMC 1251
(226)
4048 (2513)
Activated PBMC 20,237
(27,350)
25,342 (29,759)
  1. Median percent of lymphocytes activated and IQR is shown for co-cultures with the ratio of MSC/PBMC and for control cultures with PBMCs cultured alone with or without activating agent. Values within each column which have different letters are significantly different (p < 0.05). Values that are significantly greater than the PBMC alone are shown with a #. Autologous, autologous MSC co-culture (n = 1); blood donor, universal blood donor MSC co-culture (n = 3); MHC II high, MHC II-high MSC co-culture (n = 3); MHC II low, MHC II-low MSC co-culture (n = 3); PBMCs, PBMCs alone; activated PBMCs, PBMCs activated with 2.5 µg/ml of PWM