From: Immune response to allogeneic equine mesenchymal stromal cells
Autologous | Blood donor | MHC II-high | MHC II-low | ||
---|---|---|---|---|---|
ADAMTS-4 Day 3 | 1:1 | 179 (13)a | 924 (997)b,c | 371 (137)a,c | 526 (282)c |
Control | 66 (30) | 28 (20) | 90 (44) | 34 (8) | |
ADAMTS-4 Day 5 | 1:1 | 253 (50)a | 882 (444)b,c | 1087 (805)b | 671 (606)a,c |
Control | 108 (27) | 85 (21) | 117 (183) | 50 (25) | |
ADAMTS-5 Day 3 | 1:1 | 2050 (220)a | 5110 (3940)b | 2420 (610)a | 4000 (2200)a,b |
Control | 1150 (150) | 2200 (780) | 1390 (1240) | 1260 (910) | |
ADAMTS- Day 5 | 1:1 | 6990 (1450)a | 2490 (3840)a,b | 2950 (2040)a | 1540 (110)b |
Control | 1210 (260) | 2230 (680) | 1680 (1270) | 835 (1170) | |
CCL2 Day 3 | 1:1 | 14,200 (1300)a | 59,900 (25,400)b | 15,300 (8800)a | 76,600 (60,000)b |
Control | 2110 (330) | 4080 (4230) | 2840 (1140) | 4110 (3470) | |
CCL2 Day 5 | 1:1 | 10,100 (1700)a,c | 38,200 (11,400)b | 3440 (4060)a | 36,900 (19,300)a,c |
Control | 1820 (100) | 2880 (2230) | 2190 (830) | 2760 (1860) | |
IL-8 Day 3 | 1:1 | 860 (66)a | 6570 (22,200)b,c | 2770 (1460)a,c | 12,800 (17,800)b,c |
Control | 10.9 (5.4) | 146 (234) | 9.88 (10.0) | 32.2 (30.7) | |
IL-8 Day 5 | 1:1 | 66.2 (95.3)a | 2370 (3930)b | 176 (472)a | 3140 (8670)b |
Control | 2.64 (1.38) | 97.7 (70.1) | 9.6 (6.5) | 6.31 (12.7) | |
IFNÝ Day 3 | 1:1 | 9.77 (3.88)a | 392 (164)b | 6.29 (10.8)a | 492 (359)b |
Control | 2.20 (0.53) | 5.66 (6.84) | 20.8 (28.2) | 3.22 (1.27) | |
IFNÝ Day 5 | 1:1 | 21.5 (21.0)a,c | 546 (618)b | 13.4 (10.5)a | 640 (680)a,c |
Control | 2.41 (3.20) | 2.78 (2.59) | 2.25 (1.35) | 3.93 (3.53) | |
IL-1b Day 3 | 1:1 | 12.4 (6.3)a | 255 (1050)b,c | 47.1 (42.2)a,b | 460 (1457)c |
Control | 3.95 (1.53) | 11.9 (3.5) | 5.3 (11.4) | 12.6 (9.8) | |
IL-1b Day 5 | 1:1 | 32.1 (23.0)a | 230 (279)b | 22.4 (11.7)a | 352 (1016)b |
Control | 11.8 (5.0) | 13.8 (4.4) | 8.15 (9.35) | 6.15 (4.16) | |
IL-6 Day 3 | 1:1 | 16,200 (800)a,b | 50,200(24,400)a | 6240 (3310)b | 47,500 (56,200)b |
Control | 48.9 (14.6) | 1360 (1100) | 40.5 (52.2) | 234 (460) | |
IL-6 Day 5 | 1:1 | 4750 (1520)a,b | 19,500 (9200)a | 1010 (2090)b | 13,400 (6000)a |
Control | 33.6 (31.8) | 541 (111) | 24.1 (17.0 | 79.1 (283) | |
MMP-13 Day 3 | 1:1 | 315 (16)a,b | 92.7 (6945)a | 855 (372)b | 140 (47)a |
Control | 18.1 (6.9) | 181 (195) | 1010 (8550) | 368 (352) | |
MMP-13 Day 5 | 1:1 | 687 (181)a | 136 (872)a | 935 (607)a | 62.8 (70.8)b |
Control | 90.3 (19.2) | 242 (225) | 2190 (14,500) | 1010 (1040) | |
COX2 Day 3 | 1:1 | 9400 (810)a,b | 16,400 (7900)a | 7610 (2820)b | 9440 (18,700)a |
Control | 71.5 (10.3) | 3560 (4100) | 344 (1350) | 1690 (1520) | |
COX2 Day 5 | 1:1 | 8930 (4150) | 10,300 (8900) | 6290 (26,700) | 4990 (1850) |
Control | 186 (1220) | 6830 (6520) | 558 (1280) | 612 (1690) | |
TNFa Day 3 | 1:1 | 8.29 (3.65)a | 48.9 (17.5)b | 15.1 (8.5)a | 51.8 (42.1)b |
Control | 2.17 (1.27 | 6.22 (1.97) | 15.2 (10.8) | 14.2 (3.0) | |
TNFa Day 5 | 1:1 | 29.8 (31.9) | 52.1 (44.3) | 12.2 (23.9) | 63.3 (35.5) |
Control | 1.77 (0.71) | 3.65 (0.99) | 5.45 (2.32) | 4.61 (1.19) |