Skip to main content

Table 2 Delivery of RNA by MSC-EXOs

From: Mesenchymal stem cells-derived exosomes for drug delivery

RNA Exosomes origin Loading methods Administration route Model Aim References
miR-122 AMSC Transfection Intra-tumor injection Mice Enhance HCC chemosensitivity [34]
miRNA-181-5p AMSC Transfection Intrasplenic injection Mice Prevent liver fibrosis [67]
microRNA-584 BMSCs Transfection Local injection Mice Reduce glioma activity [62]
miR-132 BMSCs Electroporation Local injection Mice Promote angiogenesis [107]
LNA-anti-miR-142-3p BMSCs Electroporation Intravenous injection Mice Reduce tumorigenicity of breast cancer [88]
miR-379 BMSCs Transfection Intravenous injection Mice Reduce breast cancer activity [72]
miR-124 WJMSCs Transfection In vitro experiment GBM cancer cells Reduce glioblastoma multiform cells activity [73]
miR-133b BMSCs Transfection Intravenous injection Mice Neuroprotective role [64]
miR-145-5p HucMSCs Transfection Intra-tumor injection Mice Inhibit pancreatic ductal adenocarcinoma [91]
miR-675 HucMSCs Transfection Local injection Mice Treat aging-induced vascular dysfunction [110]
miR-126 BMSCs Transfection In vitro cell experiment N/A Ameliorate hypoxia/reoxygenation-injured ECs [108]
miR-644-5p BMSCs Transfection Intravenous injection Cisplatin-induced POF mouse mode Inhibit ovarian granulosa cell apoptosis [74]
miR-34a BMSC Transfection Intravenous injection Mice Reduce GBM activity [93]
miR-29b BMSC Transfection Intravenous injection Mice Repair spinal cord injury in rats [63]
tsRNA-10277 BMSC Transfection In vitro cell experiment N/A Enhance osteogenic differentiation ability of dexamethasone-induced BMSCs [75]
miR-126 BMSC Transfection Intravenous injection Rats Promote repair after spinal cord injury [68]
MiR-29 BMSC Transfection Local injection Rats Potential treatments for AD [96]
miR-499 BMSC Electroporation Intratumorally injected Mice Inhibit endometrial cancer growth and metastasis [76]
miR-544 BMSCs Transfection (incubate together) Intravenous injection Rats Promote repair after spinal cord injury [97]
miR-199a AMSCs Transfection Intravenous injection Mice Improve HCC chemosensitivity [66]
miR-29a BMSCs Transfection Intravenous injection Mice Promote angiogenesis and osteogenesis [112]
LNA-antimiR-142-3p BMSCs Electroporation In vitro cell experiment Mice Reduce the tumorigenicity of breast cancer stem cells in vivo [89]
miRNA-126-3p HucMSCs Transfection In vitro cell experiment and intravenous injection Mice Enhance endothelial function and attenuate vein graft neointimal formation [77]
miR-326 HucMSC Transfection Intravenous injection Mice Relieve DSS-induced IBD [78]
miR-19a/19b BMSCs Transfection Intravenous injection Mice Mitigate the damage of myocardial infarction [70]
MiR-17–92 BMSCs Transfection Intravenous injection Mice Enhance axon-myelin remodeling and motor electrophysiological recovery after stroke [65]
miR-124 BMSCs Transfection Subcutaneous injection Mice Treatment of pancreatic tumors [71]
miR-124 HADMSCs Transfection In vitro cell experiment M17 human NB cell line Therapy for NB cancer [79]
miR-214 BMSCs Transfection Intracerebroventricular injection Rats Neuroprotection against cerebral [80]
miR-381 ADMSC Electroporation In vitro cell experiment MDA-MB-231 cells Inhibit triple-negative breast cancer aggressiveness [81]
aiR-34a Dental pulp MSCs (DPSCs) Transfection (Lentiviral miR-34a transduction) In vitro cell experiment MDA-MB-231 cells Repress proliferation of breast carcinoma cells [82]
miR-135B BMSCs Transfection Articular cavity injection OA rat model Attenuate the damage of cartilage tissues [83]
miR-155-5P Synovial MSCs (SMSCs) Transfection Articular cavity injection OA rat model OA therapy [84]
miR-126 BMSCs Transfection In vitro cell experiment Human umbilical vein endothelial cells Pro-angiogenic potential [85]
MicroRNA-let7c BMSCs Lentiviral transduction Administered intravenously Rats Attenuate renal fibrosis [86]
PTEN-siRNA BMSCs Incubated Intranasal injection Rats Promote recovery for SCI [98]
miR-21 HucMSC Transfection In vitro cell experiment β-cells Treatment of diabetes [100]
miR-375 BMSCs Transfection In vitro cell experiment β-cells Treatment of diabetes [101]
miR-125a ADMSC Transfection Intravenous injection Rats Diabetic nephropathy [104]
miR-126 HucMSC Transfection Local injection Rats Diabetic eye diseases [105]
lncRNA H19 BMSCs Transfection Local injection Rats Diabetic foot ulcer [106]
  1. N/A, not applicable