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Table 2 Delivery of RNA by MSC-EXOs

From: Mesenchymal stem cells-derived exosomes for drug delivery

RNA

Exosomes origin

Loading methods

Administration route

Model

Aim

References

miR-122

AMSC

Transfection

Intra-tumor injection

Mice

Enhance HCC chemosensitivity

[34]

miRNA-181-5p

AMSC

Transfection

Intrasplenic injection

Mice

Prevent liver fibrosis

[67]

microRNA-584

BMSCs

Transfection

Local injection

Mice

Reduce glioma activity

[62]

miR-132

BMSCs

Electroporation

Local injection

Mice

Promote angiogenesis

[107]

LNA-anti-miR-142-3p

BMSCs

Electroporation

Intravenous injection

Mice

Reduce tumorigenicity of breast cancer

[88]

miR-379

BMSCs

Transfection

Intravenous injection

Mice

Reduce breast cancer activity

[72]

miR-124

WJMSCs

Transfection

In vitro experiment

GBM cancer cells

Reduce glioblastoma multiform cells activity

[73]

miR-133b

BMSCs

Transfection

Intravenous injection

Mice

Neuroprotective role

[64]

miR-145-5p

HucMSCs

Transfection

Intra-tumor injection

Mice

Inhibit pancreatic ductal adenocarcinoma

[91]

miR-675

HucMSCs

Transfection

Local injection

Mice

Treat aging-induced vascular dysfunction

[110]

miR-126

BMSCs

Transfection

In vitro cell experiment

N/A

Ameliorate hypoxia/reoxygenation-injured ECs

[108]

miR-644-5p

BMSCs

Transfection

Intravenous injection

Cisplatin-induced POF mouse mode

Inhibit ovarian granulosa cell apoptosis

[74]

miR-34a

BMSC

Transfection

Intravenous injection

Mice

Reduce GBM activity

[93]

miR-29b

BMSC

Transfection

Intravenous injection

Mice

Repair spinal cord injury in rats

[63]

tsRNA-10277

BMSC

Transfection

In vitro cell experiment

N/A

Enhance osteogenic differentiation ability of dexamethasone-induced BMSCs

[75]

miR-126

BMSC

Transfection

Intravenous injection

Rats

Promote repair after spinal cord injury

[68]

MiR-29

BMSC

Transfection

Local injection

Rats

Potential treatments for AD

[96]

miR-499

BMSC

Electroporation

Intratumorally injected

Mice

Inhibit endometrial cancer growth and metastasis

[76]

miR-544

BMSCs

Transfection (incubate together)

Intravenous injection

Rats

Promote repair after spinal cord injury

[97]

miR-199a

AMSCs

Transfection

Intravenous injection

Mice

Improve HCC chemosensitivity

[66]

miR-29a

BMSCs

Transfection

Intravenous injection

Mice

Promote angiogenesis and osteogenesis

[112]

LNA-antimiR-142-3p

BMSCs

Electroporation

In vitro cell experiment

Mice

Reduce the tumorigenicity of breast cancer stem cells in vivo

[89]

miRNA-126-3p

HucMSCs

Transfection

In vitro cell experiment and intravenous injection

Mice

Enhance endothelial function and attenuate vein graft neointimal formation

[77]

miR-326

HucMSC

Transfection

Intravenous injection

Mice

Relieve DSS-induced IBD

[78]

miR-19a/19b

BMSCs

Transfection

Intravenous injection

Mice

Mitigate the damage of myocardial infarction

[70]

MiR-17–92

BMSCs

Transfection

Intravenous injection

Mice

Enhance axon-myelin remodeling and motor electrophysiological recovery after stroke

[65]

miR-124

BMSCs

Transfection

Subcutaneous injection

Mice

Treatment of pancreatic tumors

[71]

miR-124

HADMSCs

Transfection

In vitro cell experiment

M17 human NB cell line

Therapy for NB cancer

[79]

miR-214

BMSCs

Transfection

Intracerebroventricular injection

Rats

Neuroprotection against cerebral

[80]

miR-381

ADMSC

Electroporation

In vitro cell experiment

MDA-MB-231 cells

Inhibit triple-negative breast cancer aggressiveness

[81]

aiR-34a

Dental pulp MSCs (DPSCs)

Transfection (Lentiviral miR-34a transduction)

In vitro cell experiment

MDA-MB-231 cells

Repress proliferation of breast carcinoma cells

[82]

miR-135B

BMSCs

Transfection

Articular cavity injection

OA rat model

Attenuate the damage of cartilage tissues

[83]

miR-155-5P

Synovial MSCs (SMSCs)

Transfection

Articular cavity injection

OA rat model

OA therapy

[84]

miR-126

BMSCs

Transfection

In vitro cell experiment

Human umbilical vein endothelial cells

Pro-angiogenic potential

[85]

MicroRNA-let7c

BMSCs

Lentiviral transduction

Administered intravenously

Rats

Attenuate renal fibrosis

[86]

PTEN-siRNA

BMSCs

Incubated

Intranasal injection

Rats

Promote recovery for SCI

[98]

miR-21

HucMSC

Transfection

In vitro cell experiment

β-cells

Treatment of diabetes

[100]

miR-375

BMSCs

Transfection

In vitro cell experiment

β-cells

Treatment of diabetes

[101]

miR-125a

ADMSC

Transfection

Intravenous injection

Rats

Diabetic nephropathy

[104]

miR-126

HucMSC

Transfection

Local injection

Rats

Diabetic eye diseases

[105]

lncRNA H19

BMSCs

Transfection

Local injection

Rats

Diabetic foot ulcer

[106]

  1. N/A, not applicable