Table 1 Clinical application of mesenchymal stem cells in rheumatic diseases

RA

1BM

3UC

1 × 10⁶/ kg

4

i.v

3 Relapse

1 Invalided

Safe

[14]

UC

1 × 10⁷cells

17

i.v

Modify

Safe

[17]

UC

4 × 10⁷cells × 2

(M0.3)

76

i.v

Modify

Safe

[18]

4 × 10⁷cells × 2

(M0.6)

45

4 × 10⁷cells × 2

(M0.8)

15

UC

2.5 × 10⁷cells

3

i.v

Modify

Safe

[19]

5 × 10⁷cells

3

1 × 10⁸cells

3

AD

1 × 10⁶/ kg × 3

(D1.5.18)

20

i.v

Modify

Safe

[20]

2 × 10⁶/ kg × 3

(D1.5.18)

20

4 × 10⁶/ kg × 3

(D1.5.18)

6

BM (Autologous)

1 × 10⁶/ kg

9

i.v

Modify

Safe

[21]

AS

BM

1 × 10⁶/ kg

(D0.7.14.21)

4

i.v

Modify

Safe

[32]

UC

8 × 10⁷cells (M0)

7 × 10⁷cells (M3)

5

i.v

Modify

Safe

[33]

SLE

UC

1 × 10⁶/ kg

16

i.v

Modify

Safe

[38]

BM

1 × 10⁶/ kg

26

i.v

20 Relapse

4 Infection

5 Died

[39]

UC

1 × 10⁶/ kg

61

i.v

UC

3 × 10⁷cells

20

i.v

8 Relapse

Safe

[40]

3 × 10⁷cells × 2

(D0.7)

20

UC

1 × 10⁶/kg × 2

(D0.7)

40

i.v

7 Relapse

Safe

[41]

UC

1 × 10⁶/kg × 2

(D0.7)

9

i.v

Modify

1 Died

14 Infection

[42]

UC

1 × 10⁶/kg

178

i.v

Modify

14 Died

[43]

23BM

58UC

1 × 10⁶/kg

81

i.v

Modify

4 Died

4 Infection

[45]

pSS

UC

1 × 10⁶/kg

24

i.v

Modify

Safe

[52]

PM/DM

UC

1 × 10⁶/kg

30

i.v

Modify

11 Died

[43]

UC

3.5–5.2 × 10⁷cells

37

i.v

Modify

1 Died

[56]

UC/BM

1 × 10⁶/kg

10

i.v

Modify

Safe

[57]

SSc

UC

1 × 10⁶/kg

39

i.v

Modify

6 Died

[43]

BM

0.2–1.8 × 10⁶/kg

5

i.v

Modify

1 Died

[62]

BM

1 × 10⁶/kg

14

i.v

Modify

5 Infection

[64]