Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis

Fig. 4

UCB-Exo attenuate CCl4-induced liver fibrosis and reduce collagen deposition. Liver sections were stained with Sirius red (A) and the Sirius red-positive area (red color) was determined by Ishak method (C). Immunohistochemical staining of liver sections for α-SMA (brown color) (B) in CCl4 and CCl4 + UCB-Exo groups. Collagen contents were measured in liver tissue of CCl4 and CCl4 + UCB-Exo groups (D). qRT-PCR analyses of TGF-β (E) and pro-collagen (F) expressions in liver tissue of CCl4 and CCl4 + UCB-Exo groups. Western blotting analysis of collagen type I, α-SMA, and TGF-β expressions in liver tissue of CCl4 and CCl4 + UCB-Exo groups (G). Quantification of western blot results was performed by calculating the ratio of the GAPDH. Data are presented as the mean ± SEM. Scale bar: 100 μm. *p < 0.05 and ***p < 0.001

Back to article page