Fig. 5
From: Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis
UCB-Exo increase MMP degradation in CCl4-induced liver fibrosis. qRT-PCR analyses of MMP-2 (A), MMP-9 (B), TIMP-1 (C), and TIMP-2 (D) expressions after 2 months of UCB-Exo treatment and in the CCl4 group. Western blotting assay for MMP-2, MMP-9, TIMP-1, and TIMP-2 in the liver tissue of CCl4 and CCl4 + UCB-Exo groups (E). Quantification of western blot results was performed by calculating the ratio of MMP-9 to TIMP-1 (F), the ratio of MMP-2 to TIMP-2 (G), and the ratio of the value to GAPDH (H). MMP-2 and MMP-9 activities were increased in the liver tissue of the CCl4 + UCB-Exo group compared to the CCl4 group in the third month (I). Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001