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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Nanog/NFATc1/Osterix signaling pathway-mediated promotion of bone formation at the tendon–bone interface after ACL reconstruction with De-BMSCs transplantation

Fig. 3

Tendon–bone healing 12 weeks after anterior cruciate ligament reconstruction (ACLR). a Hematoxylin and eosin staining of the tendon–bone interface. b Maximum failure load. c Stiffness. d Microcomputed tomography evaluation of the tendon–bone interface. e Bone volume/total volume (BV/TV). f Bone tunnel area. g Immunohistochemical staining for COL1A1 and quantification of the MOD at the tendon–bone interface. h mRNA expression of COL1A1 at the tendon–bone interface. i Immunohistochemical staining for OCN and quantification of the MOD at the tendon–bone interface. j mRNA expression of OCN at the tendon–bone interface. k Immunohistochemical staining for OPN and quantification of the MOD at the tendon–bone interface. l mRNA expression of OPN at the tendon–bone interface. Data represent the mean ± SD (n = 5). *p < 0.05, **p < 0.01. Scale bar = 50 μm. BMSCs bone marrow mesenchymal stem cells, De-BMSCs differentiation bone marrow mesenchymal stem cells, COL1A1 α1 chain of type I collagen, OCN osteocalcin, OPN osteopontin, MOD mean of density, B bone, IF interface T tendon

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Stem Cell Research & Therapy

ISSN: 1757-6512