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Table 1 Definition of inclusion and exclusion criteria

From: Molecular differences of adipose-derived mesenchymal stem cells between non-responders and responders in treatment of  transphincteric perianal fistulas

 

Definition

Inclusion criteria

High trans-sphincteric (> 50% of external sphincter), supra-sphincteric or extra-sphincteric fistulas

The fistula confirmed and classified by an MRI

Seton (> 6 weeks) prior to fat injection

Informed, written consent

Exclusion criteria

Anovaginal fistula

Active sepsis

IBD, immunodeficiency, prior pelvic irradiation and fistula caused by malignancy

Insulin dependent diabetes

More than 4 prior attempts of closure with sphincter saving procedures

Tobacco smoking or nicotine substitution of any kind 8 weeks prior to fat injection

Pregnancy

Psychiatric disorders

BMI ≥ 35 or BMI < 20 kg/m2

Active tuberculosis

Patient less than 18 years

Unable to undergo MRI