Skip to main content

Table 2 MicroRNAs in MS and demyelination animal models

From: Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles

miRNA Disease Model Effect in Diseased Model References
miR-21 Pediatric Multiple Sclerosis Increased levels in white matter [154]
miR-219 Demyelinating model CNS myelination and remyelination after injury, overexpression promotes early oligodendrocyte maturation [155]
miR-219 Multiple Sclerosis Necessary for production of myelinating oligodendrocytes [156]
miR-146 Multiple Sclerosis (EAE Model) Crossed the Blood Brain Barrier and significantly improved functional recovery [157]
miR-197 Pediatric Multiple Sclerosis Essential for maintaining T-cell count in patients treated with IFN-beta [154]
miR-200c Pediatric Multiple Sclerosis Increased levels in white matter [154]
miR-326a Multiple Sclerosis Increased levels in T-cell derived EVs in MS patients [158]