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Table 2 MicroRNAs in MS and demyelination animal models

From: Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles

miRNA

Disease Model

Effect in Diseased Model

References

miR-21

Pediatric Multiple Sclerosis

Increased levels in white matter

[154]

miR-219

Demyelinating model

CNS myelination and remyelination after injury, overexpression promotes early oligodendrocyte maturation

[155]

miR-219

Multiple Sclerosis

Necessary for production of myelinating oligodendrocytes

[156]

miR-146

Multiple Sclerosis (EAE Model)

Crossed the Blood Brain Barrier and significantly improved functional recovery

[157]

miR-197

Pediatric Multiple Sclerosis

Essential for maintaining T-cell count in patients treated with IFN-beta

[154]

miR-200c

Pediatric Multiple Sclerosis

Increased levels in white matter

[154]

miR-326a

Multiple Sclerosis

Increased levels in T-cell derived EVs in MS patients

[158]