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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

Fig. 6

Cell lytic effects of anti-EpCAM CAR iNK cells against cancer cells. A EpCAM expression on human breast cancer lines BT474, HTB131, MCF7 and HTB129. Black and red histograms represent isotype- and anti-EpCAM antibody-stained cells, respectively. B anti-EpCAM CAR iNK cells displayed increased cytotoxicity against EpCAM-positive cancer cell line BT474 and HTB131. The data are presented as the mean ± SD of three repeated experiments. C Expression of HLA class 1 molecules and EpCAM on iPSC-derived FLC. D Autologous iFLC cells are resistant to iNK- or CAR-iNK-mediated cytotoxicity. The data are presented as the mean ± SD of three repeated experiments. E Expression of EpCAM on normal human breast epithelial cell MCF10A. F anti-EpCAM CAR iNK cells showed little cytotoxicity against normal human breast epithelial cell MCF10A. The data are presented as the mean ± SD of three repeated experiments

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Stem Cell Research & Therapy

ISSN: 1757-6512