Fig. 5

Transplanted sevoflurane preconditioned MSCs improved cardiac function in mice after I/R. Representative images and quantification of echocardiography were shown as before I/R, 3 d and 7 d after I/R. Ejection fraction (EF), fraction shortening (FS), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) were obtained to evaluate the cardiac function in each groups. Sham, mice underwent thoracotomy but without LAD ligation; I/R, MSC and MSC + Sevo, mice subjected to ischemia (30 min) and injected with PBS, MSCs or sevoflurane preconditioned MSCs at 5 min before reperfusion. Data are shown as Mean ± SEM, n = 7 per group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus Sham; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus I/R, ⁺P < 0.05 versus MSC