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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington’s disease

Fig. 2

Injection of viral vector pAAV2-CMV-HTT171-82Q-WPRE induces HD model with motor activity deficits. A, B Stepping test. The HD rats showed a significant decrease in left forelimb activity compared to the sham and control group, but there is no difference in the right forelimb movement. C, D Cylinder test. The HD rats showed significantly decreased left forelimb asymmetric score compared to the sham and control group at week 6, but no changes were observed in the right forelimb. **p < 0.01; ***p < 0.001 significant difference between the indicated values (ANOVA). E EM48 immunohistochemistry staining to detect the Htt aggregations in the rats’ striatum. The presence of Htt aggregations in the AAV2-empty injected area (a, a’) were rarely observed. The aggregations were observed in the AAV2-Htt171-82Q injected area (b, b’)

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Stem Cell Research & Therapy

ISSN: 1757-6512