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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington’s disease

Fig. 6

Immunohistochemistry and semi-quantification results showing human embryonic stem cell transfection reverses the effect of AAV2-Htt171-82Q on microglia, astrocytes, and neurons. A, B The microglia and astrocytes were strongly activated by the infection of AAV2-Htt171-82Q (HD group) but less activated after cell transplantation (HD-ESC group). C The expression of caspase marker was increased in HD cells but get decreased after stem cell transplantation. D The neuronal marker (NeuN) was strongly expressed after cell transplantation compared with the HD group. E Oligodendrocytes marker expression in control, HD, and stem cell transplanted cell. *p < 0.05; **p < 0.01 significant difference between the indicated values (ANOVA)

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Stem Cell Research & Therapy

ISSN: 1757-6512