Reprinted from EBioMedicine, Vol (8), Li et al., Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation, p.72–82, copyright 2016, with permission from Elsevier
The inflammation in burn rats was alleviated by hUCMSC exosomes (hUCMSC-ex) . A The number of WBC in sham and burn rats treated with PBS, hUCMSC-exosomes, or hSFC-exosomes; B–D the expression levels of TNF-α, IL-1β and IL-10 in different groups; E histological images and the positive neutrophils (MPO) and macrophages (CD68) staining in burn wounds. The quantitative assay of MPO and CD68 was shown. hSFC: human skin fibroblast cell; WBC: white blood cells; PBS: phosphate-buffered saline; TNF-α: tumor necrosis factor-α; IL-1β: interleukin-1β; IL-10: interleukin-10.