Fig. 8
From: Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
Reprinted from EBioMedicine, Vol (8), Li et al., Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation, p.72–82, copyright 2016, with permission from Elsevier
The inflammation in burn rats was alleviated by hUCMSC exosomes (hUCMSC-ex) [45]. A The number of WBC in sham and burn rats treated with PBS, hUCMSC-exosomes, or hSFC-exosomes; B–D the expression levels of TNF-α, IL-1β and IL-10 in different groups; E histological images and the positive neutrophils (MPO) and macrophages (CD68) staining in burn wounds. The quantitative assay of MPO and CD68 was shown. hSFC: human skin fibroblast cell; WBC: white blood cells; PBS: phosphate-buffered saline; TNF-α: tumor necrosis factor-α; IL-1β: interleukin-1β; IL-10: interleukin-10.