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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion

Fig. 6

qPCR verified 14 upregulated miRNAs in ADSC-EVs. A Twenty-four hours after co-cultivation with fibroblast-EVs or ADSC-EVs, Arg-1 expression in microglia were detected by qPCR. ADSC-EVs were superior than fibroblast-EVs in promoting Arg-1 expression. B Heat map showed differently expressed miRNA in ADSC-EVs compared to fibroblast-EVs. C Volcano plot revealed 164 upregulated miRNAs and 120 down-regulated miRNAs in ADSC-EVs compared to fibroblast-EVs. D 14 up-regulated miRNAs were selected according to abundance more than 0.01% and conservation in human. E qPCR verified 14 up-regulated miRNAs. n = 3 per group. Data were mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512