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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: IL-6 coaxes cellular dedifferentiation as a pro-regenerative intermediate that contributes to pericardial ADSC-induced cardiac repair

Fig. 7

A proposed mechanistic loop of IL-6 mediated cardiac repair. Injection of WT1-expressing ADSC (eGFP:WT1 ADSC) into the damaged ventricular wall (myocardial infarction) led to an abundant production of interstitial IL-6 which subsequently activated its downstream nuclear target, STAT3, via IL-6/gp130 interaction on cell membrane. Activation of STAT3 in cardiomyocytes commenced a dedifferential process which warranted cardiac proliferation and regeneration of de novo cardiomyocytes for cardiac repair

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Stem Cell Research & Therapy

ISSN: 1757-6512