Fig. 4

PAI-1 inhibition by TM5275 decreases the angiogenic properties of GDM-hAMSCs. GDM-hAMSCs were treated with 100 µM TM5275. A Visual representation of tube formation assay. Two representative fields of each condition are shown. Scale bars = 100 µm. B Quantitative data represent differences in the number of extremities, nodes, junctions and meshes between GDM- and TM5275-treated GDM-hAMSCs (N = 7 in each group). Data are normalized to the mean of the controls of each experiment and are shown as mean ± SEM. Differences assessed by Student’s t test. *P < 0.05; ***P < 0.001