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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Nonwoven-based gelatin/polycaprolactone membrane loaded with ERK inhibitor U0126 for treatment of tendon defects

Fig. 4

NBM loaded with U0126 promoted tendon defect healing. A SEM documentation of NBM. B Fluorescence microscopy of TSPCs on NBM. The GFP-labeled TSPCs were cultured on the NBM for 7 days, then the cells were visualized by confocal fluorescence microscopy. C Diagram illustrating the implantation of NBM loaded with U0126 into the patellar tendon defects. DF At 4 weeks after the operation, the tendon samples were collected for histological staining and biomechanical testing. HE and Masson’s trichrome staining of tendon injury in a rat model at 4 weeks after surgery (D). Scale bar = 100 μm. (E, F) The mechanical properties of the injured tendon tissues were analyzed by biomechanical testing. The data was expressed as mean ± SD (n = 5), *p < 0.05, compared with blank control; #p < 0.05, compared with NBM group

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