Table 1 Expression levels of immune cell-related markers measured in human MuStem cells
Cell surface markers | Unstimulated hMuStem cells | TNF-α/IFN-γ-stimulated hMuStem cells | ||
|---|---|---|---|---|
Positive cells (%) | rMFI | Positive cells (%) | rMFI | |
Human leukocyte antigen | ||||
HLA-ABC | 100% | 13.3 ± 7.3 | 100% | 21.2 ± 10.3 |
HLA-DP | 29.2% ± 23.9% | 9.7 ± 4.8 | 88.3% ± 23.5% | 19.6 ± 10.5 |
HLA-E | 0% | NA | 100% | 4.0 ± 1.1 |
Immune-checkpoint ligands | ||||
Co-inhibitory factors | ||||
PDL-1 | 0% | NA | 100% | 4.0 ± 1.3 |
PDL-2 | 100% | 2.3 ± 0.3 | 100% | 3.7 ± 1.1 |
Other factors | ||||
CD155 | 100% | 12.0 ± 2.9 | 100% | 14.0 ± 3.6 |
Adhesion molecules involved in T-cell interaction | ||||
ICAM-1 | 37.4% ± 11.2% | 10.4 ± 6.0 | 100% | 284.5 ± 124.8 |
VCAM-1 | 8.3% ± 4.0% | 6.0 ± 3.7 | 100% | 5.6 ± 3.2 |