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Table 2 Secretory profile of immunoregulatory mediator by human MuStem cells and bone marrow-derived mesenchymal stem cells cultured in basal or pro-inflammatory conditions

From: Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways

 

hMuStem cells

BM-MSCs

Unstimulated

TNF-⍺/IFN-γ-stimulated

Unstimulated

TNF-⍺/IFN-γ-stimulated

Interleukins

IL-6 (ng/106 cells)

10.4 ± 2.5

34.2 ± 22.0

13.7 ± 6.8

29.7 ± 15.0

IL-8 (ng/106 cells)

13.2 ± 14.9

640.2 ± 426.3

27.9 ± 23.5

1 094.2 ± 730.1

LIF (pg/106 cells)

32 200 ± 23 300

49 870 ± 29 500

355.4 ± 130.0

847.2 ± 126.7

Growth factors

PGE2 (ng/106 cells)

6.9 ± 3.3

12.7 ± 6.7

10.1 ± 8.5

26.4 ± 18.3

VEGF (ng/106 cells)

4.1 ± 2.1

2.1 ± 1.3

7.8 ± 2.2

7.7 ± 3.0

Other factors

Galectin-1 (pg/106 cells)

44.4 ± 36

20.0 ± 21.1

56.2 ± 53.6

73.2 ± 31.8

  1. The secretory profile was determined by ELISA of culture supernatant collected 24 h after medium change. Results are expressed as the mean ± SEM or range of the concentration relative to 106 cultured cells. Each experiment was performed on 5 and 4 independent batches of hMuStem cells and bone marrow-derived mesenchymal stem cells (BM-MSCs), respectively. Stimulation corresponds to a 24-h treatment with 50 ng/mL TNF-α/IFN-γ
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Stem Cell Research & Therapy

ISSN: 1757-6512