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Table 2 Secretory profile of immunoregulatory mediator by human MuStem cells and bone marrow-derived mesenchymal stem cells cultured in basal or pro-inflammatory conditions

From: Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways

  hMuStem cells BM-MSCs
Unstimulated TNF-⍺/IFN-γ-stimulated Unstimulated TNF-⍺/IFN-γ-stimulated
Interleukins
IL-6 (ng/106 cells) 10.4 ± 2.5 34.2 ± 22.0 13.7 ± 6.8 29.7 ± 15.0
IL-8 (ng/106 cells) 13.2 ± 14.9 640.2 ± 426.3 27.9 ± 23.5 1 094.2 ± 730.1
LIF (pg/106 cells) 32 200 ± 23 300 49 870 ± 29 500 355.4 ± 130.0 847.2 ± 126.7
Growth factors
PGE2 (ng/106 cells) 6.9 ± 3.3 12.7 ± 6.7 10.1 ± 8.5 26.4 ± 18.3
VEGF (ng/106 cells) 4.1 ± 2.1 2.1 ± 1.3 7.8 ± 2.2 7.7 ± 3.0
Other factors
Galectin-1 (pg/106 cells) 44.4 ± 36 20.0 ± 21.1 56.2 ± 53.6 73.2 ± 31.8
  1. The secretory profile was determined by ELISA of culture supernatant collected 24 h after medium change. Results are expressed as the mean ± SEM or range of the concentration relative to 106 cultured cells. Each experiment was performed on 5 and 4 independent batches of hMuStem cells and bone marrow-derived mesenchymal stem cells (BM-MSCs), respectively. Stimulation corresponds to a 24-h treatment with 50 ng/mL TNF-α/IFN-γ