Fig. 5From: Engineered adipose-derived stem cells with IGF-1-modified mRNA ameliorates osteoarthritis developmentIntra-articular transplantation of IGF-1-ADSCs ameliorated OA cartilage degradation. A Schematic illustration of in vivo experiment design: the intra-articular injection was performed twice at 1 week and 2 weeks after surgery. Samples were harvested at 4 weeks or 8 weeks after surgery. B, C Typical photomicrographs of SO staining of mouse knee joints at 4 weeks (B) and 8 weeks (C) post-surgery. (Scale bar = 150 μm (left) or 100 μm (right)). D OARSI Scoring of mouse knee joints at 4 weeks (D) and 8 weeks (E) post-surgery. (ns = P > 0.05, *P < 0.05, **P < 0.01)Back to article page