Fig. 6

Intra-articular transplantation of IGF-1-ADSCs decreased the loss of extracellular matrix. A, B Immunohistochemistry staining of mouse knee joints for aggrecan and type II collagen at 4 weeks (A) and 8 weeks (B) post-surgery (Scale bar = 100 μm). C, D The ratio of Aggrecan positive cells in cartilage samples at 4 weeks (C) and 8 weeks (D) after surgery. E The relative positive intensity of type II collagen staining in cartilage samples at 4 weeks and 8 weeks after surgery (ns = P > 0.05, *P < 0.05, **P < 0.01)