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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration

Fig. 1

Root fragment mouse model for human PDL regeneration. A Root fragment transplantation into SCID. (Aa) A root fragment wrapped with PGA/PDLSC sheets. Cells were treated with vitamin C for one week as reported previously [47]; (Ab) fragments inserted into dorsal subcutaneous space of SCID mice; (Ac) root fragments retrieved ~ 3 months later and decalcified/processed for histology. B, C H&E histology of root fragments. (Ba) Root encapsulated by a layer of soft connective tissue; (Bb,c) magnified views of the PDL-like tissues. (Ca) A root fragment coronal end showing MTA (mineral trioxide aggregate) cement seal of the canal opening. The MTA is covered by a layer of mineral tissue; (Cb) magnified views of cementum-like tissue. No cementum-like tissue was observed on the root surface. Blue arrows: PDL-like tissue; red arrows: calcified cementum-like

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