Table 1 Select enriched reactome pathways identified by COL1A2 and/or LAMA3, listed in order of ascending p-values
Pathway name | p value | FDR* | Entities found |
|---|---|---|---|
Anchoring fibril formation | 1.96e-04 | 0.027 | COL1A2, LAMA3 |
MET activates PTK2 signaling | 8.80e-04 | 0.059 | COL1A2, LAMA3 |
MET promotes cell motility | 0.002 | 0.059 | COL1A2, LAMA3 |
Non-integrin membrane-ECM interactions | 0.003 | 0.084 | COL1A2, LAMA3 |
Assembly of collagen fibrils and other multimeric structures | 0.004 | 0.086 | COL1A2, LAMA3 |
ECM proteoglycans | 0.005 | 0.098 | COL1A2, LAMA3 |
Collagen formation | 0.009 | 0.111 | COL1A2, LAMA3 |
Extracellular matrix organization | 0.01 | 0.111 | COL1A2, LAMA3, EMILIN1 |
Type I hemidesmosome assembly | 0.015 | 0.111 | LAMA3 |
GP1b-IX-V activation signaling | 0.016 | 0.111 | COL1A2 |
Degradation of the extracellular matrix | 0.017 | 0.111 | COL1A2, LAMA3 |
Platelet Adhesion to exposed collagen | 0.022 | 0.111 | COL1A2 |
Crosslinking of collagen fibrils | 0.032 | 0.111 | COL1A2 |
Interleukin-4 and Interleukin-13 signaling | 0.033 | 0.111 | COL1A2 |