Table 1 OCT-4 and other stem cell markers reported in human endometrium by other groups

Usta et al. (2020)

PMID: 33218351

Reported differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas

Anwar and Amer (2021)

Reported OCT4, Ki-67 and VEFF as prognostic factors in endometrial carcinoma and their role in the differentiation between atypical endometrial hyperplasia and grade 1 endometrial carcinoma. https://doi.org/10.21608/JCBR.2021.52448.1101

Shariati et al. (2019)

PMID: 31417979

Increased expression of stemness genes REX-1, OCT-4, NANOG and SOX2 in women with ovarian endometriosis versus normal endometrium

Proestling et al. (2016)

PMID: 27881125

Reported co-expression of OCT4 with stemness markers (SOX 15 and Twist 1) in epithelial and stromal cells of endometriotic samples

Pitynski et al. (2015)

PMID: 26339387

Reported co-expression of nuclear OCT-4 and SOX2 in endometrial adeno-carcinoma tissue

Song et al. (2014)

PMID: 24884521

Higher expression of Nanog and Sox2 along with lower OCT4 mRNA and higher OCT4 protein expression in ectopic endometrium by qRT-PCR, Western blotting and IHC

Chang et al. (2013)

PMID: 23290742

Expression of OCT4 and NANOG mRNA was significantly higher in ectopic endometriotic tissues, compared with that of the normal endometrium, normal myometrium, and hyperplastic endometrium

Silveria et al. (2012)

PMID: 22940770

Reported positive immunostaining for CD9, CD34, c-Kit and Oct-4 markers in isolated epithelial and/or stromal cells in eutopic and ectopic endometrium

Zhou et al. (2011)

PMID: 21464727

Detected expression of Oct-4, Sox2 and Nanog in human endometrial adenocarcinoma samples

Götte et al. (2011)

PMID: 20850729

Reported aberrant expression of pluripotency marker SOX-2 in endometriotic samples

Cervello et al. (2011)

PMID: 21623195

Reviewed that most likely markers for endometrial somatic stem cells include Oct-4, Musashi-1, CD31, CD34, and CD144

Pachiarotti et al. (2011)

PMID: 21075367

Reported nuclear OCT-4 and c-Kit expression in epithelial and stromal cells of endometriotic endometrium suggesting a stem cell origin of endometriosis. 10 folds higher and more intense nuclear OCT-4 expression in ectopic endometriotic tissue

Bentz et al. (2010)

PMID: 20412569

OCT-4 expression was studied in human follicular (n = 49) and luteal (n = 40) phase endometrium. They detected OCT-4 mRNA and protein expression in all samples but did not find any differential expression across menstrual cycle

Forte et al. (2009)

PMID: 19690622

Differential expression of stemness markers (SOX2, SOX15, ERAS, SAL4, OCT4, NANOG, UTF1, DPPA2, BMI1, GDF3, ZFP42, KLF4, TCL1) was reported in endometrial and endometriotic tissue by RT-PCR. OCT-4 was detected in all the samples studied

Matthai et al. (2006)

PMID: 16421218

All human endometrial samples studied showed OCT-4 mRNA by RT-PCR and protein was expressed in the cytoplasm of few stromal cells