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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Fig. 8

Proposed model for GRK3-deficient BmMSCs within the niche. (A) Our studies suggest BmMSCs deficient in GRK3 secrete more CXCL12 and proliferate more rapidly, which may increase support to hematopoietic stem and progenitor cell (HSPC) development. (B, top) We propose GRK3 desensitizes S1PR and recruits β-arrestin to affect ERK1/2 signaling and receptor internalization. (B, bottom) Grk3-/- BmMSCs have enhanced functions of proliferation and osteogenic differentiation, and this may be mediated through decreased S1PR1 internalization (i.e., more surface expression) and prolonged late-phase ERK1/2 activation

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