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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway

Fig. 7

DFCs-derived CRMVs enhance osteogenic differentiation of DFCs via activating the PLC-PKC-MAPK pathway. A, B Western blot analysis demonstrated the expression of the proteins involved in the PLC-PKC-MAPK pathway in DFCs, after the incubation of 5 × 108 particles/ml MMV or CRMV for 4 days. A Representative images of the involved proteins (PLC-γ1, PKC, ERK, p-ERK, p38 and p-p38). B Quantitative evaluation on the expression state or phosphorylation level of the above proteins, GAPDH was served as the internal control. *p < 0.05, **p < 0.01, ***p < 0.001. C Schematic illustration of the isolation, functional examinations, periodontal therapeutic benefits and osteoinductive mechanism of DFCs-derived MMVs and CRMVs

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