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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomes from tendon derived stem cells promote tendon repair through miR-144-3p-regulated tenocyte proliferation and migration

Fig. 6

miR-144-3p from TDSC-Exos promoted tenocytes proliferation and migration. A The higher expression of miR-144-3p in TDSC-Exos compared with tenocytes was confirmed by qRT-PCR (Bars: mean ± SE; n = 3; unpaired Student’s t test, **p < 0.01). B Compared with PBS treatment, TDSC-Exos treatment increased miR-144-3p expression in tenocytes (Bars: mean ± SE; n = 3; unpaired Student’s t test, *p < 0.05). C miR-144-3p mimic significantly increased tenocytes proliferation, while miR-144-3p inhibitor suppressed tenocytes proliferation (Bars: mean ± SE; n = 3; unpaired Student’s t test: mimic-NC vs. miR-144-3p mimic; inhibitor-NC vs. miR-144-3p inhibitor, *p < 0.05). D Transwell assay showed that miR-144-3p mimic promoted tenocytes migration and miR-144-3p inhibitor suppressed tenocytes migration. Scale bar: 100 μm. E Quantitative analysis of the migrated cells in (D) (Bars: mean ± SE; n = 3; unpaired Student’s t test: mimic-NC vs. miR-144-3p mimic; inhibitor-NC vs. miR-144-3p inhibitor, *p < 0.05). F miR-144-3p mimic promoted tenocytes migration and miR-144-3p inhibitor suppressed tenocytes migration in scratch wound healing assay. Scale bar: 500 μm. G Quantitative analysis about the percentage of closure in (F) (Bars: mean ± SE; n = 3; unpaired Student’s t test: mimic-NC vs. miR-144-3p mimic; inhibitor-NC vs. miR-144-3p inhibitor, **p < 0.01)

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