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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells combined with autocrosslinked hyaluronic acid improve mouse ovarian function by activating the PI3K-AKT pathway in a paracrine manner

Fig. 5

HA reinforced the paracrine ability of UC-MSCs to further activate the PI3K-AKT pathway and promote follicle survival. a Scatter diagram showing the differentially expressed proteins between MSC-CM and HA/MSC-CM according to the 440-cytokine array. b KEGG pathway analysis showing many differentially expressed proteins related to the PI3K-AKT signaling pathway. c The levels of HGF, VEGF, SCF, and EGF were measured by ELISA in MSC-CM and HA/MSC-CM (n = 3). *P < 0.05. d Western blot showing the activation of the PI3K-AKT pathway by MSC-CM and HA/MSC-CM. e Immunostaining showing the expressions of DDX4 in the ovaries in the four groups after culturing for 8 days. Scale bars = 50 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512